| 摘要: |
| [摘要] 目的：探讨重复经颅磁刺激（rTMS）低频刺激辅助运动区治疗强迫障碍的疗效。方法：选择58例强迫障碍患者，随机分为药物治疗组（n=29例）、药物联合rTMS组（n=29例），于治疗前、治疗后第2、4、6、8周末行Y-BOCS评定临床疗效，TESS评定不良反应。结果：药物治疗组Y-BOCS评分在治疗的第6周、第8周末较治疗前有明显降低（P＜0.05）；rTMS治疗组Y-BOCS评分在治疗的第4周末较治疗前有明显降低（P＜0.05）；rTMS治疗组Y-BOCS评分在治疗的第4周、第6周、第8周与药物治疗组比明显下降（P＜0.05）。结论：氟西汀联合重复经颅磁刺激（rTMS）治疗强迫障碍起效快，不良反应少，安全性高。 |
| 关键词: 强迫障碍 重复经颅磁刺激 辅助运动区 |
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| A curative study of low frequency repetitive transcranial magnetic stimulation (rTMS) in supplementary motor area(SMA) combined with fluoxetine on the treatment of obsessive-compulsive disorder |
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| Abstract: |
| 【Abstract】Objective To investigate the effects of low frequency repetitive transcranial magnetic stimulation (rTMS) in supplementary motor area(SMA) combined with fluoxetine on treating patients with obsessive-compulsive disorders. Methods 58 patients were collected. They were randomly divided into medication group (29 cases) and medication combined with rTMS group (29 cases)．Obsessive-compulsive idea and behavior were assessed using Yale-Brown Obsessive Compulsive Scale(Y-BOCS) before treatment and 2,4,6,8 weeks after treatment. Adverse reaction was assessed after treatment with Treatment Emergent Symptom Scale(TESS). Results The Y-BOCS scores of the medication group decreased significantly at the 6th and the 8th week of treatment compared with before(P<0.05) while that decreased significantly at the 4th week of the rTMS group(P<0.05). There were also significant difference of the Y-BOCS scores between the rTMS group and the medication group at 4th, the 6th and the 8th of treatment(P<0.05). The rTMS group got the fewer scores. Conclusions The rTMS stimulation combined with fluoxetine in the treatment of obsessive-compulsive disorder take effect rapidly with minor adverse reactions and high security. |
| Key words: Obsessive-compulsive disorder Repetitive transcranial magnetic stimulation Supplementary motor area |