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美罗培南致AST、ALT、ALP升高的相关因素分析
梁丽娟, 王谦
泸州市合江县人民医院药剂科
摘要:
目的:探究使用美罗培南后发生的AST、ALT、ALP值升高是否与性别,年龄,用药疗程之间是否有关系。 方法:对某院使用过注射用美罗培南药物的住院病人进行分析,将AST、ALT、ALP升高的患者数分别对其性别,年龄,用药疗程进行卡方分析,考察它们相关性是否具有统计学意义。结果:111名纳入研究范围,其中共有11名患者(占总人数的9.91%)出现AST升高,9名患者(占总人数的8.11%)出现ALT升高,有10名患者(占总人数的9.01%)出现ALP升高。三种转氨酶分别对性别、年龄、用药疗程进行卡方分析,其P值均大于0.05。结论:使用美罗培南后AST、ALT、ALP的升高与性别、年龄和用药疗程无相关性。
关键词:  美罗培南 转氨酶升高 相关因素 卡方分析
DOI:
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基金项目:
Analysis of the related factors of AST.ALT.ALP elevation in patients with meropenem
Abstract:
Abstract:Objective: In order to explore whether the increase in AST,ALT, and ALP values after the use of meropenem was associated with gender, age, and course of treatment. Methods: The inpatients who used meropenem for injection in a hospital were analyzed. The number of patients with elevated AST, ALT and ALP were analyzed by chi-square method for their gender, age and course of treatment, and the correlation between them was investigated. Results: 111 patients were included in the study. Among them, 11 patients (9.91% of the total) had elevated AST, 9 patients (8.11% of the total) had elevated ALT, and 10 patients (9.01% of the total) had elevated ALP. Chi-square analysis on sex, age and treatment course showed that all the P values were greater than 0.05. Conclusion: The elevation of AST, ALT and ALP after meropenem administration was not correlated with sex, age and course of treatment.
Key words:  meropenem  Transaminase elevation  Relevant factors  Chi-square  analysis
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