| 摘要: |
| 目的本研究通过检测慢性阻塞性肺疾病（COPD）稳定期及急性加重期患者血清正五聚蛋白3（PTX3）的表达水平,探讨其与病情发展的关系。方法选择宜宾市第一人民医院呼吸内科2014年3月至2015年3月确诊为慢性阻塞性肺疾病患者60例,另取同期条件下27例健康体检者,以ELISA法测定血浆PTX-3浓度,比较各组间的差距,同时检测高敏C反应蛋白（hs CRP）、肺功能及CAT问卷评分。结果慢性阻塞性肺疾病急性发作期患者PTX-3浓度为（609.85±329.35）ng/mL,明显高于稳定期患者（70.48±32.48）ng/mL及健康体检者（1.04±0.98）ng/mL,差异有统计学意义（P<0.01）;稳定期患者的PTX3水平又明显高于健康体检者,差异有统计学意义（P<0.01）;血清PTX3与FEV1、FEV1（%）、FVC（L）呈负相关,与hsCRP,CAT问卷评分呈正相关（P<0.01）。结论作为炎症指标PTX-3与hsCRP、症状、肺功能有较好的相关性,在一定程度上决定着COPD的严重程度,且在急性加重期和稳定期具有差异性的高表达,更利于COPD的分期,有望成为评判COPD严重程度的一种新的指标。 |
| 关键词: 正五聚蛋白3 慢性阻塞性肺疾病 炎症指标 |
| DOI： |
| 分类号: |
| 基金项目:宜宾市级科研项目(编号:2013YZY004) |
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| Clinical Significance of Serum Positive Five Protein 3 in Patients With Chronic Obstructive Pulmonary Disease and Its Correlation With High Sensitive C Reactive Protein |
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Li Hanchun;Tang Fengming;Luo Linjie1,2
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1.West China Hospital of Sichuan University;2.Yibin First People’s Hospital
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| Abstract: |
| Objective To investigate the expression of serum five-poly 3( PTX3) in patients with chronic obstructive pulmonary disease( COPD) in stable and acute exacerbation,and to explore its relationship with the development of the disease.Methods We selected 60 cases of patients diagnosed with chronic obstructive pulmonary disease in Yibin First People’s Hospital from March 2014 to March 2015 and 27 cases of physical examination of healthy people during the same time and measured plasma PTX-3 concentration by ELISA method. The gap between the groups was compared,and the high sensitivity C reactive protein( hs CRP),lung function and CAT questionnaire score were detected.Results PTX-3 concentration of patients with acute exacerbation chronic obstructive pulmonary disease was( 609. 85±329. 35) ng/mL,which was significantly higher than that of patients in stable stage( 70. 48±32. 48) ng/mL and healthy subjects( 1. 04 ± 0. 98) ng/mL( P < 0. 01). The PTX3 levels of patients in stable stage was significantly higher than that of healthy subjects( P<0. 01).Serum PTX3 was negatively correlated with FEV1,FEV1( %)and FVC( L),and positively correlated with the scores of hs CRP and CAT( P<0. 01).Conclusion As a marker of inflammation,PTX-3 has a good correlation with hs CRP,symptoms and lung function.It determines the severity of COPD to a certain extent.And its expression in the acute exacerbation and stable stage were significantly different,higher in acute phase,contributing to the stage of COPD.PTX-3 is expected to become a new index for judging the severity of COPD. |
| Key words: positivefiveprotein3 chronicobstructivepulmonarydisease Inflammatorymarker |
