| 摘要: |
| 目的探讨预测局部进展期直肠癌新辅助放化疗后病理完全缓解(pCR)的临床相关因素。方法回顾性分析2013年10月至2016年9月间我科收治的53例局部进展期直肠癌并接受新辅助放化疗和手术的患者临床资料,采用单因素分析及Logistic多因素分析法研究预测病理完全缓解(pCR)的相关临床因素。结果 53例患者有11例(20.8%)达到pCR。单因素分析显示,新辅助化疗方案(P=0.019)、年龄(P=0.048)与新辅助放化疗后的pCR率相关。多因素回归分析结果显示,新辅助化疗方案(OR=0.078,P=0.045)是影响新辅助放化疗后pCR率的唯一独立因素。结论奥沙利铂+氟尿嘧啶类药物的新辅助化疗方案可以获得更好的pCR率。 |
| 关键词: 直肠肿瘤 新辅助放化疗 病理完全缓解 预测 |
| DOI： |
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| Clinical Study on Predicting Pathologic Complete Response after Neoadjuvant Chemoradiotherapy for Locally Advanced Rectal Cancer |
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Hu Hai;Yan Jin;Liu Chao;
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Sichuan Cancer Hospital & Institute,Sichuan Cancer Center,School of Medicine,University of Electronic Science and Technology of China
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| Abstract: |
| Objective To explore clinical parameters that could predict pathologic complete response( pCR) after neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Methods The retrospective study involved 53 patients with locally advanced rectal cancer,who underwent neoadjuvant chemoradiotherapy followed by surgery between October 2013 and September2016.Univariate analysis and multivariate logistic regression analysis were performed to identify clinical factors associated with pCR. Results Among 53 patients,11( 20. 8%) achieved pCR status.Univariate analysis found that neoadjuvant chemotherapy regimens( P = 0. 019) and age( P = 0. 048) were significantly correlated with pCR.Multivariate logistic regression analysis revealed that neoadjuvant chemotherapy regimens( OR = 0. 078,P = 0. 045) was the unique independent predictor of pCR.Conclusion Neoadjuvant chemotherapy with oxaliplatin and fluorouracil after neoadjuvant chemoradiotherapy for locally advanced rectal cancer achieved high rate of pCR |
| Key words: rectalneoplasms neoadjuvantchemoradiotherapy pathologiccompleteresponse predictor |
