| 摘要: |
| 目的探讨右美托咪啶复合舒芬太尼PCIA用于食道癌手术术后镇痛对机体免疫细胞的影响。方法选择食道癌根治术患者132例,随机分为复合组（A组）与舒芬太尼组（B组）。PCIA给药方案;A组:右美托咪啶1μg/kg,舒芬太尼2μg/kg,托烷司琼10mg;B组舒芬太尼2μg/kg,托烷司琼10mg。分别用于麻醉诱导前（T0）、气管导管拔除即刻（T1）、术后12h（T2）、术后24h（T3）、术后48h（T4）、术后72h（T5）,对外周血管中CD3+、CD4+、CD8+淋巴细胞亚群及NK细胞含量进行检测,并计算CD4+/CD8+值,并观察术后不良反应发生情况。结果 A组患者术后T2-T5时不良反应发生率明显低于B组,差异有统计学意义（P<0.05）;与T0时比较,两组患者T1-T5时CD3+、CD4+、CD4+/CD8+和NK细胞水平均降低。A组患者T2-T5时CD3+水平和CD4+/CD8+均明显高于B组,A组T3-T5时,CD4+和NK细胞水平明显高于B组,差异有统计学意义（P<0.05）。结论右美托咪啶复合舒芬太尼PCIA用于食管癌术后镇痛可降低镇痛时不良反应的发生,改善患者细胞免疫功能,有利于患者预后。 |
| 关键词: 食管癌 右美托咪啶 免疫细胞 |
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| Effects of Dexmedetomidine Combined with Sufentanil on Immune Cells in Postoperative Analgesia of Esophageal Cancer Patients |
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Ran Maorong;Lin Lu;Niu Jie
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General Hospital of Chengdu Military Region
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| Abstract: |
| Objective To investigate the effect of dexmedetomidine combined with sufentanil PCIA on immune cellsin postoperative analgesia of esophageal cancer patients.Methods 132 patients with esophageal cancer radical calcification were randomly divided into two groups: combination group（group A） and sufentanil group（group B）.PCIA dosing regimen,Group A: dexmedetomidine 1μg/kg,sufentanil 2μg/kg,tropisetron 10mg; Group B: sufentanil 2μg/kg,tropisetron 10 mg.Administration time werebefore anesthesia induction（T0）,tracheal tube extraction immediately（T1）,postoperative 12h（T2）,postoperative 24h（T3）,postoperative 48h（T4）,postoperative 72h（T5）.Peripheral blood vessels CD3+,CD4+,CD8+ lymphocyte subsets and NK cells were measured and the CD4+/CD8+ ratio was calculated.The incidence of adverse reactions was observed.Results The incidence of adverse events was significantly lower in group A（T2-T5） than that in group B（P< 0.05）.Compared with T0,the levels of CD3+,CD4+,CD4+/CD8+and NK cells were reduced（T1-T5） in both groups.The levels of CD3+and CD4+/CD8+ in group A were significantly higher than those in group B（T2-T5）.And the levels of CD4+ and NK cells in group A were significantly higher than those in group B（T3-T5）（P<0.05）.Conclusion Dextemethamine combined with sufentanil PCIA for postoperative analgesia in esophageal cancer can reduce the incidence of adverse reactions during analgesia and improve the cellular immune function of patients,which is beneficial to the prognosis of patients. |
| Key words: esophagealcancer dexmedetomidine immunecells |
