| 摘要: |
| 目的比较噻托溴铵与噻托溴铵联合羧甲司坦片对慢性阻塞性肺疾病(COPD)的疗效。方法选取78例稳定期慢性阻塞性肺疾病患者,随机分为对照组及观察组。其中对照组给予噻托溴铵18μg吸入,1次/d;观察组在对照组基础上联合应用羧甲司坦片500mg,3次/d,治疗6个月观察两组患者的疗效。结果治疗后,观察组及对照组CAT评分、急性加重次数均明显改善(P<0.05),治疗后两组间比较差异有统计学意义(P<0.05);两组第1s用力呼气量(FEV1)、FEV1%Pred、用力肺活量(FVC)较治疗前均明显改善,但两组间差异无统计学意义(P>0.05);两组不良反应发生差异无统计学意义(P>0.05)。结论噻托溴铵联合羧甲司坦片治疗稳定期慢性阻塞性肺疾病患者具有良好的协同作用,能改善患者的临床症状,减少急性加重次数,改善肺功能,提高生活质量。 |
| 关键词: 噻托溴铵 羧甲司坦 慢性阻塞性肺疾病 |
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| Observationof the Curative Effect of Tiotropium Bromide Combined with Carbocisteine Tablets in Treatment of Chronic Obstructive Pulmonary Disease |
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Hu Ling;Li Weiming;Yang Wei
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Department of Respiratory Medicine,the Sixth People’s Hospital of Chengdu
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| Abstract: |
| Objective To comparethe curative effect of tiotropium bromide and tiotropium bromide combined with carbocisteine tablets on chronic obstructive pulmonary disease（ COPD） patients. Methods 78 patients with stable chronic obstructive pulmonary disease were selected and randomly divided into the control group and the observation group.The control group was treated with inhalation of tiotropium bromide18μg 1 time/d,while the observation group was given combined application of Carbocisteine Tablets 500 mg 3 times/d,on the basis of the control group. After 6 months of treatment,the curative effect of the two groups was observed.Results After treatment,the scores of CAT and acute exacerbation in the observation group and the control group were obviously improved（ P<0. 05）,and the difference between the two groups was statistically significant（ P < 0. 05）; The forced expiratory volume in the first second（ FEV1）,FEV1%Pred,and forced vital capacity（ FVC） of the two groups were significantly better than those before treatment（ P<0. 05）,but the difference between the two groups was not statistically significant（ P>P>0. 05）; There was no significant difference in adverse reactions between the two groups（ P > 0. 05）. Conclusion Tiotropium bromide combined with carbocisteine tablets in treatment ofpatients with stable chronic obstructive pulmonary disease has good synergistic effect,can improve the clinical symptoms of patients,reduce the frequency of acute exacerbation,improve lung function,and improve the quality of life. |
| Key words: tiotropiumbromide carbocysteine chronicobstructivepulmonarydisease |
